Report title: Interaction between Vaccina virus and host cells

Abstract: Vaccina virus (VACV) is a double-stranded DNA virus, originally used as a vaccine against smallpox. Although smallpox has become the only disease that has been successfully eliminated through vaccination in human history, researches on VACV are still ongoing. Using the VACV infection model, it is possible to study the antiviral mechanism in cells/in vivo. At the same time, the long genome of VACV also allows it to load antigens of other pathogens. Therefore, VACV can be used as a potential carrier for a variety of vaccines. Recently the ZAP/TRIM25/KHNYN complex is discovered to be essential for the antiviral effect of cells and VACV can specifically target this protein complex to escape the antiviral mechanism of cells, thereby hijacking organelles to serve the virus replication . Through the study of its mechanism, it is possible to deepen the understanding of the cell's antiviral mechanism and the understanding of the dynamic interaction between virus hosts, which can provide new ideas for the development of antiviral drugs.

Speaker: Associate Professor Dong Li

Reporting time: 13:30 pm, Friday, 25th September, 2020

Reporting method: Tencent meeting

Conference ID: 228 317 011