所在学科专业：

基础医学 人体解剖学

研究方向：

心脑血管

讲授课程：

人体解剖学，PBL，人体疾病药物

教育经历：

2012.09 – 2016.07，新葡的京集团8814，药学院，学士

2016.09 – 2021.06，新葡的京集团8814，新葡的京集团8814，博士（硕博连读）

工作经历：

2022.03–至今  新葡的京集团8814，新葡的京集团8814，人体解剖学系，讲师

科研项目：

1. 肠道菌群代谢产物SCFAs基于PKM2介导DCs代谢重编程影响心梗后组织修复的乙酰化机制研究，编号：2022B23，白求恩医学部，2022.07- 2024.09，经费：5万元，项目负责人；

2. C3AR1介导肠心轴调控心梗后修复的乙酰化机制研究，编号：JJKH20241323KJ，吉林省教育厅，2024.01-2025.12，经费：2.5万元，项目负责人；

3. 颈康胶囊的二次开发研究，编号：No. 20230401082YY，吉林省科学技术厅，2023.01-2025.12，经费：85万元，参与人；

4. CDK5调控树突状细胞在低氧损伤中的作用机制研究，编号：20180101168JC，吉林省科技厅，2018.01-2020.12，经费：15万元，参与人；

5. 水凝胶搭载生物活性物质改善心肌梗死后组织修复的应用开发研究，编号：2019C049-4，吉林省发改委，2019.01-2020.12，经费：10万元，参与人。

学术论文：

发表文章（近三年，10篇以内）

1. Tongtong Song, Xin Guan, Xuan Wang, Shanshan Qu, Siwei Zhang, Wenting Hui, Lihui Men and Xia Chen^*. Dynamic modulation of gut microbiota improves post-myocardial infarct tissue repair in rats via butyric acid-mediated histone deacetylase inhibition. FASEB JOURNAL. 2021 Mar;35(3). (IF: 5.834)

2. Tongtong Song, Rongjin Wang, Xiaoyue Zhou, Weijia Chen, Ying Chen, Zhongying Liu, Lihui Men. Metabolomics and molecular dynamics unveil the therapeutic potential of epalrestat in diabetic nephropathy. Int Immunopharmacol. 2024 Oct 25:140:112812 (IF: 5.6)

3. Tongtong Song, Wenting Hui, Min Huang, Yan Guo, Meiyi Yu, Xiaoyu Yang, Yanqing Liu, Xia Chen^*. Dynamic Changes in Ion Channels during Myocardial Infarction and Therapeutic Challenges. Int J Mol Sci. 2024 Jun 12;25(12):6467. (IF: 5.6)

4. Tongtong Song^#; Yiwen Gu^#; Wenting Hui; Xiaoyu Yang; Yanqing Liu; Xia Chen^*; Oxygen–Glucose Deprivation Promoted Fibroblast Senescence and Collagen Expression via IL11, International Journal of Molecular Sciences. 2022, 23(20): 12090. (IF: 6.208)

5. Xuan Wang, Tongtong Song, Yunpeng Sun, Lihui Men, Yiwen Gu, Siwei Zhang and Xia Chen^*. Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen-Glucose Deprivation Conditions. Journal of Proteome Research. 2021,20(1): 960-971. (IF: 5.370)

6. Wenting Hui, Tongtong Song, Ling Yu, Xia Chen^*. The Binding of HSPA8 and Mitochondrial ALDH2 Mediates Oxygen-Glucose Deprivation-Induced Fibroblast Senescence. Antioxidants (Basel). 2023 Dec 25;13(1):42. (IF: 7)

7. Lihui Men, Wenting Hui, Xin Guan, Tongtong Song, Xuan Wang, Siwei Zhang, Xia Chen^*. Cardiac transcriptome analysis reveals nr4a1 mediated glucose metabolism dysregulation in response to high-fat diet. Genes, 2020,11(7). (IF: 4.141)

8. Hongyun Jiang#; Siwei Zhang#; Tongtong Song; Xin Guan; Ruojin Zhang; Xia Chen* ;Trichostatin a Protects Dendritic Cells Against Oxygen-Glucose Deprivation via the SRSF3/PKM2/ Glycolytic Pathway, Frontiers in Pharmacology, 2018, 9: 612. (IF：5.988)

著作教材：

获奖情况：

高等医药院校一流课堂设计作品展示 一等奖（金课堂）

社会兼职：

中国解剖学会会员